Library / English Dictionary

TARGET CELL

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

An abnormal red blood cell with the appearance of a dark ring surrounding a dark center; associated with anemia

Classified under:

Nouns denoting body parts

Hypernyms ("target cell" is a kind of...):

erythrocyte; RBC; red blood cell (a mature blood cell that contains hemoglobin to carry oxygen to the bodily tissues; a biconcave disc that has no nucleus)

Sense 2

Meaning:

Any cell that has a specific receptor for an antigen or antibody or hormone or drug, or is the focus of contact by a virus or phagocyte or nerve fiber etc.

Classified under:

Nouns denoting body parts

Hypernyms ("target cell" is a kind of...):

somatic cell; vegetative cell (any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes)

Credits

 Context examples: 

Activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement cascades (classical or properdin pathway) generate Membrane Attack Complex, which creates target cell wall pores and lysis.

(Complement Degradation Process, NCI Thesaurus)

Any physiologic process which occurs in response to ligation of the platelet activating factor receptor, and results in a reduced number of active signaling molecules within the target cell.

(Negative Regulation of Platelet Activating Factor Signaling, NCI Thesaurus)

In addition, modification of elbow hinge sequences within the antibody variable framework regions may account for the strong apoptosis-inducing activity of R7159 upon binding to CD20 on target cells.

(Obinutuzumab, NCI Thesaurus)

Any physiologic process which occurs in response to ligation of an interleukin receptor with a cognate ligand, and results in a reduced number of active signaling molecules within the target cell.

(Negative Regulation of Interleukin Signaling, NCI Thesaurus)

Any physiologic process which occurs in response to ligation of an immunologic factor receptor with its cognate ligand, and results in a reduced number of active signaling molecules within the target cell.

(Negative Regulation of Immunologic Factor Signaling, NCI Thesaurus)

Activating receptors bind ligands on the target cell surface and trigger NK cell activation and target cell lysis.

(Natural Killer Cell-Mediated Cytotoxicity Pathway, NCI Thesaurus/KEGG)

This process is involved in direct lysis of target cells, immune adherence and phagocytosis of pathogens, and recruitment and activation of immunocompetent cells.

(Complement Activation, NCI Thesaurus)

Any physiologic process which occurs in response to ligation of a colony stimulating factor receptor with a cognate ligand, and results in a reduced number of active signaling molecules within the target cell.

(Colony Stimulating Factor Suppression, NCI Thesaurus)

Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription.

(Aldosterone-Regulated Sodium Reabsorption Pathway, NCI Thesaurus/KEGG)

“This is due to the fact that there are tremendous obstacles: identifying suitable catalysts and reactions and, above all, delivering the catalysts directly into the target cells, and not others.”

(Scientists successfully deliver “Trojan horse” catalysts into cancerous tumour cells to destroy them from within, Universities of Granada)