| Library / English Dictionary |
TELOMERASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide
Classified under:
Hypernyms ("telomerase" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Context examples:
Complementary to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding.
(Imetelstat Sodium, NCI Thesaurus)
Upon administration, ovarian cancer stem cell/hTERT/survivin mRNAs-loaded autologous DC-006 vaccine may elicit a highly specific cytotoxic T-cell (CTL) response against ovarian cancer cells expressing hTERT, survivin, and specific ovarian cancer stem cell antigens. hTERT, the catalytic subunit of human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types, playing key roles in tumor cell growth and survival.
(Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine, NCI Thesaurus)
Upon administration, hTERT/survivin/melanoma tumor cell-derived mRNA-transfected dendritic cell vaccine may elicit a highly specific cytotoxic T-cell (CTL) response against melanoma cells expressing hTERT, survivin, and patient-specific melanoma-associated antigens. hTERT, the catalytic subunit of human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types, playing key roles in tumor cell growth and survival.
(hTERT/Survivin/Melanoma Tumor Cell-Derived mRNA-Transfected Dendritic Cell Vaccine, NCI Thesaurus)
A peptide-based cancer vaccine consisting of two human leukocyte antigen (HLA)-A*0201 restricted 9-mer epitopes derived from the human telomerase reverse transcriptase (hTERT), TERT 572Y (YLFFYRKSV; TYR-Vx001) and TERT 572 (RLFFYRKSV; ARG-Vx001), with potential immunostimulating and antineoplastic activities.
(HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001, NCI Thesaurus)
The BMVC/G-quadruplex complexes also interfere with the activity of telomerase, which is highly active in tumor cells and plays a key role in tumorigenesis while expressed at very low levels in most somatic cells.
(G-Quadruplex Stabilizer BMVC, NCI Thesaurus)
This protein plays a role in both microtubule binding and the inhibition of telomerase.
(PIN2/TERF1-Interacting Telomerase Inhibitor 1, NCI Thesaurus)
Abnormally reactivated in tumorigenesis, telomerase is expressed in the majority of human cancer cells but is not expressed or is expressed at very low levels in normal cells.
(hTERT Vaccine V934/V935, NCI Thesaurus)
Telomerase specifically elongates the 3-prime end of a single-stranded overhang region on the G-rich 3-prime strand while the C-rich strand can be filled in by DNA polymerases.
(Elongation by Telomerase, NCI Thesaurus)
FJ5002 inhibits telomerase by interfering with holoenzyme assembly and telomere interaction, thus leading to replication-dependent shortening of telomeres with a concurrent increase in aneuploid metaphases and apoptotic cells.
(FJ5002, NCI Thesaurus)
A cancer vaccine containing autologous dendritic cells (DCs) that are transfected with mRNAs extracted from amplified ovarian cancer stem cells, and mRNAs of the universal tumor antigens human telomerase reverse transcriptase (hTERT) and survivin with potential immunostimulatory and antineoplastic activities.
(Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine, NCI Thesaurus)
