Health / Medical Topics |
Terfenadine
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways. (NCI Thesaurus)
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Human TERF2IP wild-type allele is located in the vicinity of 16q23.1 and is approximately 113 kb in length. This allele, which encodes…
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This gene is involved in both telomere maintenance and gene transcription.
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Human TERF2 wild-type allele is located in the vicinity of 16q22.1 and is approximately 30 kb in length. This allele, which encodes…
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This gene is involved in the negative regulation of telomerase activity.
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TERF1 (TRF1)-Interacting Nuclear Factor 2 (TINF2), encoded by the TINF2 gene, is a 50-kD telomere-associated protein. TINF2 regulates telomere length and prevents…
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Human TERF1 wild-type allele is located in the vicinity of 8q13 and is approximately 39 kb in length. This allele, which encodes…
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