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THALASSEMIA
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I. (noun)
Sense 1
Meaning:
An inherited form of anemia caused by faulty synthesis of hemoglobin
Synonyms:
Mediterranean anaemia; Mediterranean anemia; thalassaemia; thalassemia
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("thalassemia" is a kind of...):
monogenic disease; monogenic disorder (an inherited disease controlled by a single pair of genes)
hypochromic anaemia; hypochromic anemia (anemia characterized by a decrease in the concentration of corpuscular hemoglobin)
Hyponyms (each of the following is a kind of "thalassemia"):
Cooley's anaemia; Cooley's anemia; thalassaemia major; thalassemia major (a fatal form of homozygous thalassemia (inherited from both parents) in which there is no hemoglobin; skeletal deformations; heart and spleen and liver enlarged)
Context examples:
Causes include acromegaly, Hurler syndrome, Silver-Russell syndrome, and thalassemia major.
(Frontal Bossing, NCI Thesaurus)
A severe and rare form of alpha thalassemia characterized by the absence of alpha globin chains.
(Hemobglobin Bart's Hydrops, NCI Thesaurus)
The new approach can be useful to diagnose infectious disorders associated with anaemia (such as malaria) and to screen for genetic anaemias such as thalassemia and sickle cell disease.
(New approach promises better anaemia detection, SciDev.Net)
They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.
(Heinz Body, NLM, Medical Subject Headings)
Red blood cell transfusions are commonly given to critically ill children for conditions such as trauma, cancer chemotherapy, intraoperative bleeding, and chronic conditions such as sickle cell disease and thalassemia.
(Fresh red blood cell transfusions do not help critically ill children more than older cells, National Institutes of Health)
A heterozygous state in which a person has a mutation in a beta globin allele causing beta thalassemia, together with other structural variants in the other allele.
(Beta Thalassemia Plus Structural Variants, NCI Thesaurus)
Doctors use these transplants to treat people with certain diseases, such as: • Leukemia • Severe blood diseases such as thalassemias, aplastic anemia, and sickle cell anemia • Multiple myeloma • Certain immune deficiency diseases
(Bone Marrow Transplantation, NIH: National Heart, Lung, and Blood Institute)
Conditions that may lead to anemia include: • Heavy periods • Pregnancy • Ulcers • Colon polyps or colon cancer • Inherited disorders • A diet that does not have enough iron, folic acid or vitamin B12 • Blood disorders such as sickle cell anemia and thalassemia, or cancer • Aplastic anemia, a condition that can be inherited or acquired • G6PD deficiency, a metabolic disorder
(Anemia, NIH: National Heart, Lung, and Blood Institute)
A division of the National Heart, Lung, and Blood Institute that supports research on the causes, prevention, and treatment of nonmalignant blood diseases, including anemias, sickle cell disease, and thalassemia; premalignant processes such as myelodysplasia and myeloproliferative disorders; hemophilia and other abnormalities of hemostasis and thrombosis; and immune dysfunction.
(Division of Blood Diseases and Resources, NCI Thesaurus)
People with mutation or deletion of the beta-subunit gene have Beta-thalassemias resulting from an over-abundance of alpha subunits and their precipitation.
(Hemoglobin Chaperone Pathway, NCI Thesaurus/BIOCARTA)
