| Library / English Dictionary |
THYMIDINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A nucleoside component of DNA; composed of thymine and deoxyribose
Synonyms:
Classified under:
Hypernyms ("thymidine" is a kind of...):
nucleoside (a glycoside formed by partial hydrolysis of a nucleic acid)
Context examples:
Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation.
(Mitoguazone, NCI Thesaurus)
FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine triphosphate production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
(Capecitabine Rapidly Disintegrating Tablet, NCI Thesaurus)
This agent is not catabolized and has a long half-life compared to the radioconjugate carbon C 11 thymidine.
(Fluorine F 18 d-FMAU, NCI Thesaurus)
Examples of these include cytidine, uridine, adenosine, guanosine, thymidine, inosine and others.
(Nucleoside, NCI Thesaurus)
Cesalin intercalates into and crosslinks DNA and inhibits the incorporation of the nucleotides uridine and thymidine into DNA, thereby inhibiting DNA and protein synthesis.
(Cesalin, NCI Thesaurus)
In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability.
(Arginine butyrate, NCI Thesaurus)
A gene viral vector complex comprised of a replication-defective adenovirus and a herpes simplex virus thymidine kinase gene that activates ganciclovir, causing inhibition of DNA synthesis and apoptosis.
(Adenovirus RSV-TK, NCI Thesaurus)
An RGD-4C-modified, infectivity-enhanced, bicistronic type 5 adenovirus expressing herpes simplex virus thymidine kinase (HSV-tk) gene, a therapeutic suicide gene, and the somatostatin receptor type 2 (SSTR2) gene with potential antineoplastic activity.
(Ad5.SSTR/TK.RGD, NCI Thesaurus)
Buciclovir is phosphorylated to its triphosphate form by HSV thymidine kinase in infected cells and acts as a specific inhibitor of the viral DNA polymerase.
(Buciclovir, NCI Thesaurus)
FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
(Capecitabine, NCI Thesaurus)
