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TNF
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
Synonyms:
TNF; tumor necrosis factor; tumour necrosis factor
Classified under:
Hypernyms ("TNF" is a kind of...):
cytokine (any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system)
Context examples:
BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies.
(Belimumab, NCI Thesaurus)
OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor family, is expressed by CD4 T cells and provides a costimulatory signal for T cell activation.
(Anti-OX40 Monoclonal Antibody, NCI Thesaurus)
DR5 is a tumor cell surface ligand that crosslinks with death receptor type 4 (DR4) when bound by TRAIL [Tumor necrosis (TNF)-related apoptosis-inducing ligand], triggering apoptosis via a death receptor signaling pathway.
(Anti-DR5 Agonist Monoclonal Antibody TRA-8, NCI Thesaurus)
May induce apoptosis through the TNF pathway.
(Adenovirus 5-CD40 Ligand, NCI Thesaurus)
CD30, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on activated lymphocytes transiently and is constitutively expressed in hematologic malignancies including Hodgkin's disease and some T-cell non-Hodgkin's lymphomas.
(Anti-CD30 Monoclonal Antibody MDX-1401, NCI Thesaurus)
CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is overexpressed in hematologic malignancies; CD16A is specifically expressed on the surface of NK cells.
(Anti-CD30/CD16A Monoclonal Antibody AFM13, NCI Thesaurus)
CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell carcinoma (RCC) cells among other cancer cell types.
(Anti-CD70 Monoclonal Antibody MDX-1411, NCI Thesaurus)
CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on a number of solid and hematological tumors.
(Anti-CD70 Monoclonal Antibody ARGX-110, NCI Thesaurus)
CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells.
(Anti-CD70 Antibody-Drug Conjugate MDX-1203, NCI Thesaurus)
This agent is also a potent inducer of interferon and a spectrum of cytokines such as IL-1, IL-6, and tumor necrosis factor (TNF).
(Ammonium Trichlorotellurate, NCI Thesaurus)
