Library / English Dictionary

TO A LESSER EXTENT

 I. (adverb) 

Sense 1

Meaning:

Used to form the comparative of some adjectives and adverbs

Example:

less quickly

Synonyms:

less; to a lesser extent

Classified under:

Adverbs

Credits

 Context examples: 

Normal cells provide enough asparagine for their own needs through biosynthesis and are affected to a lesser extent by this treatment.

(Catabolic Pathway for Asparagine and Aspartate, NCI Thesaurus/BIOCARTA)

To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.

(Albuterol Sulfate, NCI Thesaurus)

This anticoagulant binds to antithrombin III, thereby enhancing the inactivation of activated factor X (Factor Xa) and, to a lesser extent, activated factor II (Factor IIa).

(Bemiparin Sodium, NCI Thesaurus)

A decrease can happen in both scenarios — business-as-usual (increase in temperature above 3 degrees Celsius by 2100) and strong mitigation (below 1.7 degrees Celsius by 2100) — but to a lesser extent in a low emissions scenario.

(Pacific island fish migrating to cooler seas, SciDev.Net)

Danaparoid sodium binds to antithrombin III and inhibits the activity of activated factor X (factor Xa) and, to a lesser extent, activated factor II (thrombin) thereby preventing fibrin formation.

(Danaparoid Sodium, NCI Thesaurus)

By inhibiting mTOR to a lesser extent than PI3K, PQR309 does not interfere with the mTOR-mediated negative feedback loop on PI3K signaling.

(pan-PI3K/mTOR Inhibitor PQR309, NCI Thesaurus)

Combining two pharmacological moieties, a somatostatin analogue and a dopamine agonist, dopamine-somatostatin chimeric molecule BIM-23A760 binds with high affinity to dopamine D2 receptor (D2R) and somatostatin receptor subtype 2 (SSTR2), and to a lesser extent to somatostatin receptor subtype 5 (SSTR5).

(Dopamine-Somatostatin Chimeric Molecule BIM-23A760, NCI Thesaurus)

Aminoflavone activates the aryl hydrocarbon receptor (AhR) signaling pathway leading to an increase in cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1A2 (CYP1A2) expression and, to a lesser extent, an increase in cytochrome P450 1B1 (CYP1B1) expression.

(AFP464, NCI Thesaurus)

Radiolabeled amino acid-based agents are useful in PET brain tumor imaging because F-18 fluoro-deoxyglucose (F-18 FDG), commonly used in PET tumor imaging, is relatively insensitive for detecting tumors in the brain due the high levels of glycolytic metabolism in the normal cortex and to a lesser extent in white matter.

(Fluoroethyltyrosine F18, NCI Thesaurus)

Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted.

(Cycloleucine, NCI Thesaurus)