Health / Medical Topics

    Tositumomab

    Pronunciation

    Definition 1

    A drug used together with another drug to treat certain types of B-cell non-Hodgkin lymphoma. It is also being studied in the treatment of other types of cancer. Tositumomab binds to a protein called CD20, which is found on the surface of B cells, and may kill cancer cells. It is a type of monoclonal antibody. (NCI Dictionary)

    Definition 2

    A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B-cells. Tositumomab binds to the CD20 surface membrane antigen, resulting in apoptosis, and may stimulate antitumoral cell-mediated and/or antibody-dependent cytotoxicity. (NCI Thesaurus)

    Definition 3

    A monoclonal antibody that is used in the treatment of certain types of non-Hodgkin lymphoma. When tositumomab and iodine I 131 tositumomab (a form of tositumomab that has been chemically changed by adding radioactive iodine) are given together, the combination is called the Bexxar regimen. (NCI Dictionary)




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