Health / Medical Topics |
Transformation
Pronunciation
Definition 1
In medicine, the change that a normal cell undergoes as it becomes malignant. (NCI Dictionary)
Definition 2
The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events. (NCI Thesaurus)
YOU MAY ALSO LIKE
![](/lib/px2x1.gif)
A substance being studied in the treatment of brain tumors. Transferrin-CRM107 is made by linking a diphtheria toxin to transferrin, a protein…
![](/lib/px2x1.gif)
The determination of the iron bound to transferrin in a sample.
![](/lib/px2x1.gif)
A cationic liposomal, tumor-targeting p53 (TP53) gene delivery system with potential anti-tumor activity. Transferrin receptor-targeted liposomal p53 cDNA contains plasmid DNA encoding…
![](/lib/px2x1.gif)
A proprietary transferrin receptor-targeted nanoparticle preparation of a non-chemically modified small-interfering RNA (siRNA) directed against the M2 subunit of ribonucleotide reductase (RRM2)…
![](/lib/px2x1.gif)
Human transferrin protein (698 aa, 77 kDa precursor) is encoded by the human transferrin (TF) gene. The protein is a serum beta-globulin…
![](/lib/px2x1.gif)
Regulated by mitogenic stimulation and cellular iron levels (through IRP1/2), TFRC Gene (M28B Peptidase Family) encodes 760-aa 85-kDa Transferrin Receptor 1, a…
![](/lib/px2x1.gif)