Library / English Dictionary

TUMOR NECROSIS FACTOR

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

Synonyms:

TNF; tumor necrosis factor; tumour necrosis factor

Classified under:

Nouns denoting substances

Hypernyms ("tumor necrosis factor" is a kind of...):

cytokine (any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system)

Credits

 Context examples: 

This allele, which encodes BAG family molecular chaperone regulator 4 protein, plays a role in the regulation of apoptosis through the suppression of both tumor necrosis factor receptor signaling and protein chaperone function.

(BAG4 wt Allele, NCI Thesaurus)

NGFR was the first member of the large superfamily of tumor necrosis factor receptors.

(Nerve Growth Factor Receptor, NCI Thesaurus)

This allele, which encodes tumor necrosis factor receptor superfamily member 16 protein, plays a role in several biological process through signal transduction.

(NGFR wt Allele, NCI Thesaurus)

In addition, this agent modulates inflammatory responses through various mechanisms, including the inhibition of both the release of reactive oxygen species (ROS) from neutrophils and tumor necrosis factor (TNF)-alpha activity.

(PI3K Delta/Gamma Inhibitor RP6530, NCI Thesaurus)

OX-40 is a type of tumor necrosis factor (TNF) receptor.

(OX-40, NCI Dictionary)

Inhibition of these processes results in suppression of the production of proinflammatory cytokines, such as tumor necrosis factor alpha and interleukin 6.

(Acai Berry Juice, NCI Thesaurus)

This agent is also a potent inducer of interferon and a spectrum of cytokines such as IL-1, IL-6, and tumor necrosis factor (TNF).

(Ammonium Trichlorotellurate, NCI Thesaurus)

This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor.

(MEK Inhibitor MEK162, NCI Thesaurus)

CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell carcinoma (RCC) cells among other cancer cell types.

(Anti-CD70 Monoclonal Antibody MDX-1411, NCI Thesaurus)

CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on a number of solid and hematological tumors.

(Anti-CD70 Monoclonal Antibody ARGX-110, NCI Thesaurus)