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VIRION
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I. (noun)
Sense 1
Meaning:
(virology) a complete viral particle; nucleic acid and capsid (and a lipid envelope in some viruses)
Classified under:
Hypernyms ("virion" is a kind of...):
particle; subatomic particle (a body having finite mass and internal structure but negligible dimensions)
Meronyms (parts of "virion"):
capsid (the outer covering of protein surrounding the nucleic acid of a virus)
Domain category:
virus ((virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein)
Context examples:
Fibronectin fragment CH-296 is used in retroviral-based gene transfer procedures, which utilizes adhesive property of fibronectin to bring virions to target cells and to facilitate co-localization, thereby increasing gene transfer efficiency.
(Fibronectin Fragment CH296, NCI Thesaurus)
This protein is involved in the transfer of ubiquitin to target proteins and may play a role in virion budding from infected cells and tumor suppression.
(E3 Ubiquitin-protein Ligase NEDD4 Protein, NCI Thesaurus)
These proteins are involved in both the release of the viral genome into infected cells and the subsequent repackaging of the replicated genome into new virions.
(Flu Matrix Protein, NCI Thesaurus)
The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attenuated, replication-defective vaccinia strain incapable of virion assembly.
(MVA-FCU1 TG4023, NCI Thesaurus)
Virions are enveloped, ether-sensitive, and vary up to 200 nm in diameter; the nucleocapsids are 100 nm in diameter and of icosahedral symmetry, with 162 capsomeres.
(Herpesvirus, NCI Thesaurus)
Originally developed for the eradication of smallpox, MVA is a highly attenuated and replication-defective strain incapable of virion assembly and exerts potent immunostimulatory activity against antigens.
(MVA-MUC1-IL2 Vaccine, NCI Thesaurus)
Its virion contains linear double-stranded DNA, terminally redundant, and circularly permuted.
(Bacteriophage T4, NLM, Medical Subject Headings)
Indinavir selectively binds to the active site of human immunodeficiency virus (HIV) protease and inhibits its activity, preventing the protease-mediated cleavage of gag-pol viral polyproteins; as a result immature, noninfectious virions are produced.
(Indinavir Sulfate, NCI Thesaurus)
A genus of viruses (family Papovaviridae) containing DNA, having virions about 55 nm in diameter, and including the papilloma and warts viruses of man and other animals, some of which are associated with inductions of carcinoma.
(Papillomavirus, NCI Thesaurus)
Upon infusion into the hepatic artery, oncolytic HSV-1 rRp450 replicates in hepatocellular carcinoma (HCC) cells and exerts direct cytotoxic effects eventually disrupting cancer cell membranes and liberating progeny virions thereby infecting adjacent tumor cells.
(Oncolytic HSV-1 rRp450, NCI Thesaurus)
